The Cincinnati Fire Department underwent a major reorganization of the EMS system on April 5, 2011. Prior to that date the city was served by 4 ALS ambulances designated as "Rescues" and 8 BLS transport units designated as "Ambulances". On April 5, the process was completed to convert all of the ambulances to ALS units. The unit designation was also changed at this time to "Medic" which follows the standard nomenclature used by the rest of the fire departments in Hamilton County.
At the time of the reorganization, the EMS Field Supervisor was running as Rescue 2 out of Station 2. This unit was moved to Station 34 and the designation was changed to ALS 34. A second field supervisor went into service in 2012 as ALS 32 running out of Station 32 and a third supervisor was added in 2013 as ALS 38 running out of Station 38. It was subsequently relocated to Station 35 where it is currently running as ALS 35.
In 2012, unit identifiers were added to all Medic and ALS units. This was a major change for the department since unit numbers had previously been left off all non-fire suppression related apparatus.
In June of 2022, two new ambulances were received for Medic 9 and Medic 12, and they marked a return to a solid red paint scheme.
In 2025, the department conducted a 90 day trial on utilizing two-person paramedic chase cars to reduce run volume on the engine and truck companies. After the successful conclusion of the trial, Chase Car 1 (CC 1) and Chase Car 2 (CC 2) were placed into service in May. CC 1 was initially located at Station 35 and subsequently moved to
Station 51. CC 2 is located at Station 2.